Here’s why we prefer that any backup drive purchased for a Mac have at least FireWire 400, if not 800 also:
FireWire has its own processor, where USB relies on the CPU of your computer to figure out how data should be transferred. So, when you’re moving files to and from a USB drive, it can affect the performance of your computer, while FireWire shoulders the burden itself. Since every Mac except the MacBook has FireWire, it’s worth the few extra bucks to get that on your external hard drive.
Reference: http://www.technibble.com/firewire-vs-usb/